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The Bottom Line Weight loss medications like semaglutide, tirzepatide, and phentermine can powerfully support your journey but the quality of your weight loss matters just as much as the quantity

The problem is, some people don't make enough GLP-1, which might contribute to weight gain and obesity

Tirzepatide is administered as a once-weekly subcutaneous injection, with a recommended starting dose of 2.5 mg once weekly for 4 weeks, then increasing by 2.5 mg every 4 weeks until the target dose (up to 15 mg) is reached

Since there are no approved medicines, pills, or procedures that increase melanin production, many people tan in the sun or in indoor tanning beds to stimulate cells to produce more pigment

(2025) [123], showing that weight regain typically begins around eight weeks after discontinuation and continues through week 20, with the early posttreatment phase being especially vulnerable

Do not interpret a lack of dramatic effects as a sign that the medication is not working