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Pre-existing gastrointestinal conditions People with irritable bowel syndrome, gastroparesis, gastroesophageal reflux disease, or chronic constipation are significantly more likely to experience early and intense side effects

Alternative evidence-based interventions, including structured lifestyle programmes, psychological support, other pharmacological options, and bariatric surgery (for those meeting criteria), may be more readily accessible and should be considered as part of an individualised treatment plan

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Thyroid concerns are the reason every semaglutide product carries a boxed warning