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That observation became the foundation for one of the most extensively cited copper-peptide research lines in tissue-biology literature, and its the reason GHK-Cu is still classified in research today as an endogenous signaling peptide rather than a synthetic compound designed from scratch

These employ one or several TCF binding sites followed by either a fluorescent reporter or the enzyme beta-galactosidase to detect Wnt-responsive cells (DasGupta and Fuchs, 2003

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"Just like if you go to Hawaii, get tan and then you leave and the tan fades, because you've taken away the stimulus," she said

doi: 10.1126/scitranslmed.3005616 74 YehYTHarouakaRAZhengSY

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