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Docosahexaenoic (DHA) modulates phospholipid-hydroperoxide glutathione peroxidase (Gpx4) gene expression to ensure self-protection from oxidative damage in hippocampal cells
In a 12 month RCT in adults with type 2 diabetes comparing intermittent energy restriction (20922510 kJ [500600 kcal] diet for 2 non-consecutive days/week followed by the usual diet for 5 days/week) with continuous energy restriction (50216276 kJ [12001500 kcal] diet for 7 days/week), glycaemic improvements were comparable between the two groups
The article lists headaches or migraines, skin irritations or rashes, digestive issues including bloating and diarrhea, nasal congestion or sinus issues, and fatigue or anxiety
Like melanotan I, this analog is more potent than natural -MSH but has more side effects because it is less receptor-specific
The ACP also highlights that the recommendations are a living guideline, which will be regularly updated as new research emerges