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In practice, I usually see better tolerance with half portions, softer preparation, and gradual increases
How Side Effects Are Usually Managed In Practice Providers often start at a low dose and increase slowly to reduce GI symptoms
This pharmacologic property distinguishes it from small-molecule therapeutics where hepatic impairment dramatically alters drug-drug interaction profiles
Huttasch M, Roden M, Kahl S
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The FDA-approved use of this medication varies according to the brand names
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