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Common metabolic barriers include: Hormonal imbalance Age-related metabolic slowdown Insulin resistance Chronic inflammation Poor mitochondrial function As metabolism slows, the body becomes more resistant to fat loss

also observed a significant increase in lncRNA XIST expression in thyroid cancer tissues and cell lines

rare complications include allergic reactions and hypokalaemia during treatment of severe anaemia

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Demonstrated positive response defined as 5% reduction from baseline body weight (adults) or baseline BMI (pediatrics), or maintenance of weight loss with continued participation in a weight management program

Some studies suggest that this may contribute to frailty and other medical problems common in older age