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The article's table puts constipation at 20 to 30 percent for semaglutide and 25 to 35 percent for tirzepatide, and suggests the dual GIP and GLP-1 action may raise the risk through its effects on gut motility

But heres something many people dont realize: Your body already knows how to make GLP-1

First, a substantial portion of the mechanistic and translational data derives from preclinical studies or small human cohorts, which may not fully capture understudied aspects of aging that vary across populations