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Compounded versions require patients to draw precise amounts from vials, which has led to reported administration errors where patients accidentally injected doses up to 10 times higher than prescribed, causing severe nausea, vomiting, abdominal pain, and weakness

It needs to be applied to the entire face for an even skin tone

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However, while they are recognized for their skin-lightening and brightening effects, the outcomes can vary and are not always predictable

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